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Mesothelioma Support for California patients/people

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What is Mesothelioma?

Mesothelioma is a form of cancer most often caused by asbestos , that affects the smooth lining of the lungs, heart,abdomen and testicles.The tissue that lines your lungs, heart,abdomen and other organs is called mesothelium which protects the bodies internal organs by forming a smooth and slippery protective layer.The disease advances when asbestos fibers accumulate in the mesothelium lining causing inflammation and scarring leading to the formation of cancerous mesothelial cells within the mesothelium. Mesothelioma is a tumor of that tissue.Once inside the body, asbestos has the potential to slowly damage DNA in ways that cause a cell to become cancerous. Once a cell turns cancerous, it replicates uncontrollably, resulting in a buildup of cells that slowly forms into a tumor. malignant(cancerous) cells multiply in uncotrolled manner and from the mesothelium can invade,damage nearby tissues and organs thus spreading to other parts of the body.Mesothelioma is unique in the way it grows. Most tumors form as a singular mass. But mesothelioma tumors more commonly develop as numerous small nodules on the lining of the lungs or abdomen.Tumors originating in the lung lining will first affect pulmonary health, while those developing in the abdominal lining will first affect the digestive system.

Mesothelioma has a latency period of 10-50 years, meaning the disease takes a decade or more to develop after exposure to asbestos. It is caused when people inhale or ingest asbestos fibers.Around 3,000 people are diagnosed in the U.S. every year. Most of them were exposed on the job.

Types of Mesothelioma

1.Pleural Mesothelioma
this is the most common type of malignant mesothelioma
the name relates to the location where it develops, the pleura, which means the tissue lining the lungs.
symptoms
persistent chest pain,difficulty swallowing,night sweat or fever,peristent dry cough,shortness of breath,Reduced lung expansion.

2.Peritoneal Mesothelioma
develops in the mesothelial lining of the abdomen, known as the peritoneum,faster in spreading throughout the body.
symptoms
constipation or diarrhea, fatigue, abdominal swelling or pain,unexplained weight loss,nausea and vomiting,Fluid buildup,Hernias,Abdominal distension.
These symptoms are related to the thickening of the peritoneal membrane and the build-up of fluid.

3.Pericardial Mesothelioma
location of the cancer is on the exterior lining of the heart, known as the pericardium
occurs due to the accumulation of fluid in the spaces between the layers of the pericardium.
symptoms
irregular heart beats,chest pain or pain under the rib cage, trouble in breathing, coughing of blood, night sweats or fever, and fatigue.

4.Testicular Mesothelioma
developed in the lining of the testicles, a tissue known as tunica vaginalis. It is the rarest type of mesothelioma.
a complete list of symptoms has not been established, but it is known that painless testicular lumps and swelling of scrotum.

Mesothelioma Cell Types

In addition to location and whether the disease is malignant or not, the type of cells also differs among mesotheliomas

a)Epithelial Mesothelioma:
Epithelial mesothelioma cells are the most common cell types that are organized and structured, accounting for about 50 to 75% of all cases.can be seen microscopically as uniformly shaped, with an elongated pattern and visible nuclei.

b)Sarcomatoid Mesothelioma:
They are random and irregular, growing out of supportive structures like muscles or bones. Under the microscope, these cells are elongated and spindle-shaped, without a nucleus.thus the diagnosis is more difficult as they resemble healthy tissue,resistant to treatment, resulting in a poor prognosis.

c)Biphasic Mesothelioma:
these cells include a mix of both epithelials and sarcomatoids.there is no specific structure,they tend to form in differentiated groups in different areas of the tumor.Treatment can be difficult,based on multi-modal therapy that combines radiation and chemotherapy. Surgery is also an option, but only in early stages.

d)Papillary Mesothelioma:
A rare variation of epithelioma cells. usually found in women, particularly the ones in reproductive ages.usually develop in the lining of the abdomen but they are benign in the majority of the cases.Among men, it can also develop in the tunica vaginalis.This type of mesothelioma is painless and does not spread to other parts of the body, and the prognosis is favorable.either surgery, chemotherapy, or radiation therapy are the course of treatments.

mesothelioma cancer is difficult to detect as it may start with a thickening of the pleural rind, or fluid which can be associated with many other conditions.The symptoms of mesothelioma gradually become more noticeable, prompting the patient to seek a medical consultation. By this time the progression of the disease may already be too advanced as the tumor may have spread to the lymph nodes and/or begun to metastasize(distant spreading) to remote organs of the body like the brain, spleen, liver or kidneys. Metastatic mesothelioma is considered late stage and incurable, given the current state of treatments.

It is widely reported that only 10-20% of patients with pleural mesothelioma are diagnosed early enough for surgical intervention, the rest are referred on to palliative care.

The stage of the mesothelioma cancer is a measure of how aggressive the cancer is and whether it has spread to other parts of the body. Early stage mesothelioma, in Stage 1 or Stage 2, is localized to a small area. Early stage mesothelioma is often curable by surgically removing all of the tumor.

In later stages of the disease, such as Stage 3 or Stage 4, the tumor or tumors have enlarged and the cancer has traveled. At these stages, the cancer may end up traveling within the affected organ and through the lymph system or bloodstream to land on distant areas in the bone or other tissues.

Stage 4 disease is considered incurable and often no surgery is performed. Instead, radiation therapy and chemotherapy are given to shrink the tumor and to prolong the patient’s life. Having these treatments can prolong your life and improve the quality of it.

Physical signs of mesothelioma usually arise in later stages of development. It is rare for stage I or II mesothelioma to cause noticeable symptoms.All of the treatments are meant to improve patients’ quality of life since there is currently no cure for any type of mesothelioma.

List of Mesothelioma Consultants in USA:

Dr. Robert J. Cerfolio
University of Alabama School of Medicine
ZRB 739
1720 2nd Avenue South
Birmingham, AL 35294
(205) 934-5937

Jonathan Daniel, M.D.
North Campus
3838 N. Campbell Ave.
Tucson, AZ 85719
(520) 626-6339

Linda L. Garland, M.D.
North Campus
3838 N. Campbell Ave.
Tucson, AZ 85719
(520) 626-3434

Matthew A. Steliga, M.D.
University of Arkansas for Medical Sciences
4301 West Markham Street
Little Rock, AR 72205
(501) 686-7000

Robert Brian Cameron, M.D.
10780 Santa Monica Boulevard, Suite 100
Los Angeles, CA 90024
(310) 267-4612

David M. Jablons, M.D.
Helen Diller Family Comprehensive Cancer Center
1600 Divisadero Street, Fourth Floor
San Francisco, CA 94143
(415) 885-3882

Mark R. Cullen, M.D.
1265 Welch Rd
Stanford, CA 94305
(650) 721-6296

Mark W. Lischner, M.D.
Pulmonary Medicine Associates
5 Medical Plaza Drive, Suite 190
Roseville, CA 95661
(916) 786-7498

D. Ross Camidge, M.D.
Mesothelioma Clinic
1665 Aurora Court
Aurora, CO 80045
(720) 848-0300

Robert C. Doebele, M.D.
Mesothelioma Clinic
1665 Aurora Court
Aurora, CO 80045
(720) 848-0300

Frank C. Detterbeck, M.D.
333 Cedar Street, WWW 205
New Haven, CT 06520
(203) 200-5864

Jack A. Elias, M.D.
100 Grand Street
New Britain, CT 06050
(860) 224-5661

Carrie Redlich, M.D.
135 College Street, 3rd floor
New Haven, CT 06510
(203) 737-2817

Gregory A. Masters, M.D.
Medical Oncology Hematology Consultants
4701 Ogletown-Stanton Road, S-3400
Newark, DE 19713
(302) 366-1200

Charles R. Mulligan, Jr., M.D.
4701 Ogletown-Stanton Road, S-2100
Newark, DE 19713
(302) 623-4530

Lary Robinson, M.D.
12902 Magnolia Drive
Tampa, FL 33612
(813) 745-8412

Daniel L. Miller, M.D.
1365 Clifton Road NE
Atlanta, GA 30322
(404) 778-3755

Michele Carbone, M.D.
701 Ilalo Street
Honolulu, HI 96813
(808) 440-4596

Philip D. Bonomi, M.D.
Section of Medical Oncology
1725 W. Harrison Street, Suite 1010
Chicago, IL 60612
(312) 942-5904

Michael J. Liptay, M.D.
Rush Professional Office Building
1725 W. Harrison Street, Suite 774
Chicago, IL 60612
(312) 738-3732

Wickii Thambiah Vigneswaran, M.D.
2160 S. First Avenue
Maywood, IL 60153
(888) 584-7888

Laurence Bates, M.D.
Indiana Oncology Hematology Consultants
8111 S. Emerson Avenue, Suite A
Indianapolis, IN 46237
(317) 859-5252

Anita Conte, M.D.
Indiana Oncology Hematology Consultants
8111 S. Emerson Avenue, Suite A
Indianapolis, IN 46237
(317) 859-5252

Michael Slaughter, M.D.
Indiana Oncology Hematology Consultants
8111 S. Emerson Avenue, Suite A
Indianapolis, IN 46237
(317) 859-5252

Gerald H. Clamon, M.D.
Holden Comprehensive Cancer Center
200 Hawkins Drive
Iowa City, IA 52242
(319) 356-4200

Chao Huang, M.D.
Westwood Medical Pavilion and the Richard and Annette Bloch Cancer Care Pavilion
2330 Shawnee Mission Parkway, MS 5003
Westwood, KS 66205
(913) 588-1227

Timothy W. Mullett, M.D.
138 Leader Avenue
Lexington, KY 40506
(859) 323-6494

Brian L. Pettiford, M.D.
Ochsner Medical Center
1514 Jefferson Hwy.
New Orleans, LA 70121
(504) 842-3966

Tracey L. Weigel, M.D.
Maine Medical Center Cancer Institute
Division Director of Thoracic Surgery
818 Congress Street
Portland, ME 04102
(207) 773-8161

Stephen C. Yang, M.D.
600 N. Wolfe Street Blalock 240
Baltimore, MD 21287
(410) 614-3891

Raffit Hassan, M.D.
Center for Cancer Research/National Cancer Institute
Building 37, Room 5116
Bethesda, MD 20892
(301) 451-8742

Raphael Bueno, M.D.
75 Francis Street
Boston, MA 02115
(617) 732-8148

Scott Swanson, M.D.
75 Francis Street
Boston, MA 02115
(617) 732-6824

Shirish M. Gadgeel, M.D.
4100 John R Street
Detroit, MI 48201
(313) 576-8753

Robert Kratzke, M.D.
Masonic Cancer Clinic
420 Delaware Street SE, MMC 480
Minneapolis, MN 55455
(612) 624-5944

Pierre E. De Delva, M.D.
University of Mississippi Medical Center
2500 North State Street
Jackson, MS 39216
(601) 815-2005

Traves D. Crabtree, M.D.
Barnes-Jewish Hospital
Queeny Tower, 3108
One Barnes-Jewish Hospital Plaza
St. Louis, MO 63110
(314) 362-8089

Brian W. Loggie, M.D.
Alegent Creighton Clinic Surgical Oncology
601 North 30th Street #2803
Omaha, NE 68131
(402) 280-5292

Nicholas J. Vogelzang, M.D.
Central Valley Treatment Center
3730 S. Eastern Avenue
Las Vegas, NV 89169
(702) 952-3400

Cherie P. Erkmen, M.D.
Dartmouth-Hitchcock Medical Center
One Medical Center Drive
Lebanon, NH 03756
(603) 650-8537

Bruce G. Haffty, M.D.
195 Little Albany Street
New Brunswick, NJ 08903
(732) 235-3939

Jess D. Schwartz, M.D.
University of New Mexico Cancer Center
2211 Lomas Boulevard Northeast
Albuquerque, NM 87106
(505) 272-2336

Raja M. Flores, M.D.
One Gustave L. Levy Place
New York, NY 10029
(212) 241-9466

Harvey Pass, M.D.
530 First Avenue
New York, NY 10016
(212) 263-7417

Shahriyour Andaz, M.D.
One Healthy Way
Oceanside, NY 11572
(516) 255-5010

Andrea S. Wolf, M.D.
1470 Madison Avenue, 3rd Floor
New York, NY 10029
(212) 241-9502

Sai Yendamuri, M.D.
Elm and Carlton Streets
Buffalo, NY 14263
(716) 845-2300

David H. Harpole, M.D.
2424 Erwin Road, Suite 403
Durham, NC 27705
(919) 668-8413

David P. Carbone, M.D.
The James–Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
300 West 10th Avenue
Columbus, OH 43210
(800) 293-5066

James Stevenson, M.D.
Mail Code R35
9500 Euclid Avenue
Cleveland, OH 44195
(216) 444-6833

Daniel Nader, M.D.
10109 E. 79th Street (81st Street & Highway 169)
Tulsa, OK 74133
(918) 286-5000

Paul H. Schipper, M.D.
OHSU Knight Cancer Institute
3181 SW Sam Jackson Park Road, L353
Portland, OR 97239
(503) 494-7820

Steven M. Albelda, M.D.
3615 Civic Center Boulevard
Philadelphia, PA 19104
(215) 573-9933

Joel D. Cooper, M.D.
Hospital of the University of Pennysylvania
3400 Civic Center Boulevard
Philadelphia, PA 19104
(215) 662-2022

Larry R. Kaiser, M.D.
Department of Cardiothoracic Surgery
3401 N. Broad Street
Philadelphia, PA 19140
(215) 707-7000

David Ettensohn, M.D.
73 Beechwood Avenue
Pawtucket, RI 02860
(401) 724-4040

Sundaresan T. Sambandan, M.D.
1220 Pontiac Avenue
Cranston, RI 02920
(401) 943-4660

Alice Boylan, M.D.
Hollings Cancer Center at the Medical University of South Carolina
96 Jonathan Lucas Street, C.S.B. Suite 812 MSC 630
Charleston, SC 29425
(843) 792-5626

Ashraf A. Elshami, M.D.
Sanford Health/Sanford Pulmonary Medicine Clinic
1205 S Grange Avenue, Suite 407
Sioux Falls, SD 57105
(605) 328-8900

Eric S. Lambright, M.D.
Vanderbilt University Medical Center
1710 The Vanderbilt Clinic
Nashville, TN 37232
(615) 322-0064

David Sugarbaker, M.D.
The Michael E. DeBakey Department of Surgery
One Baylor Plaza, Mail Stop BCM 390
Houston, TX 77030
(713) 798-MESO (6376)

Kemp Kernstine, M.D.
UT Southwestern Medical Center
5323 Harry Hines Boulevard
Dallas, TX 75390
(214) 645-7700

Anne Tsao, M.D.
1515 Holcombe Boulevard, Unit 432
Houston, TX 77030
(713) 792-6363

Joan H. Schiller, M.D.
2201 Inwood Rd., Suite 106
Dallas, TX 75390
(214) 645-4673

Amit N. Patel, M.D.
2000 Circle of Hope
Salt Lake City, UT 84112
(801) 585-0303

Claire Verschraegen, M.D.
Hematology/Oncology Division, UVM Given College of Medicine Building
89 Beaumont Avenue, Suite E-214
Burlington, VT 05405
(802) 656-5487

James M. Isbell, M.D.
University of Virginia Cancer Center
Cardiac Surgery Clinic
University Hospital, 2nd floor
1215 Lee Street
Charlottesville, VA 22908
(434) 243-6443

Howard Jack West, M.D.
5300 Tallman Ave NW
3rd Floor
Seattle, WA 98107
(206) 386-2424

Dr. Eric Vallieres
Swedish Cancer Institute-Surgical Practices
1101 Madison Street, Suite 850
Seattle, WA 98104
(206) 215-6800

Paul H. Sugarbaker, M.D.
106 Irving Street NW, Suite 3900
Washington, DC 20010
(202) 877-3908

Arthur N. Mcunu, Jr., M.D.
Howard University Hospital
2041 Georgia Avenue
Washington, DC 20060
(202) 865-6100

Nepal C. Chowdhury, M.D.
St. Mary’s Cardiovascular and Thoracic Surgeons
2828 First Avenue, Suite 200
Huntington, WV 25702
(304) 399-7530

H. Ian Robins, M.D.
Department of Medicine
600 Highland Avenue
Madison, WI 53792
(608) 263-8090

Robert Winter, M.D.
Papworth Everard
Cambridge
CB23 3RE
01480 830 541


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